Endometriosis is defined as the presence of endometrial cells outside of the uterus that can result in pain, distortion of pelvic structures and infertility. Various reports in the medical literature suggest that endometriosis is related to a deficiency in the immune system. Impaired immune response in some women may result in ineffective removal of the endometrial cells from the pelvic area that may result in endometriosis. A number of substances are involves in the pathophysiology of the disease including cytokines and natural killer cells. Although a number of theories have been proposed in the development of endometriosis, the exact pathophysiology is still to be determined.
The natural conception rate for healthy ovulating women in their early 30s (without endometriosis) is approximately 15-20% per month and 75-85% per year of actively attempting to conceive